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Marta Ligero; Alonso Garcia Ruiz; Cristina Viaplana; Guillermo Villacampa; Maria V Raciti; Jaid Landa; Ignacio Matos; Juan Martin Liberal; Maria Ochoa de Olza; Cinta Hierro; Joaquin Mateo; Macarena Gonzalez; Rafael Morales Barrera; Cristina Suarez; Jordi Rodon; Elena Elez; Irene Braña; Eva Muñoz-Couselo; Ana Oaknin; Roberta Fasani; Paolo Nuciforo; Debora Gil; Carlota Rubio Perez; Joan Seoane; Enriqueta Felip; Manuel Escobar; Josep Tabernero; Joan Carles; Rodrigo Dienstmann; Elena Garralda; Raquel Perez Lopez |
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A CT-based radiomics signature is associated with response to immune checkpoint inhibitors in advanced solid tumors |
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Journal Article |
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2021 |
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Radiology |
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299 |
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1 |
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109-119 |
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Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue. |
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IAM; 600.145 |
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Admin @ si @ LGV2021 |
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3593 |
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Carlos Martin Isla; Victor M Campello; Cristian Izquierdo; Kaisar Kushibar; Carla Sendra Balcells; Polyxeni Gkontra; Alireza Sojoudi; Mitchell J Fulton; Tewodros Weldebirhan Arega; Kumaradevan Punithakumar; Lei Li; Xiaowu Sun; Yasmina Al Khalil; Di Liu; Sana Jabbar; Sandro Queiros; Francesco Galati; Moona Mazher; Zheyao Gao; Marcel Beetz; Lennart Tautz; Christoforos Galazis; Marta Varela; Markus Hullebrand; Vicente Grau; Xiahai Zhuang; Domenec Puig; Maria A Zuluaga; Hassan Mohy Ud Din; Dimitris Metaxas; Marcel Breeuwer; Rob J van der Geest; Michelle Noga; Stephanie Bricq; Mark E Rentschler; Andrea Guala; Steffen E Petersen; Sergio Escalera; Jose F Rodriguez Palomares; Karim Lekadir |
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Deep Learning Segmentation of the Right Ventricle in Cardiac MRI: The M&ms Challenge |
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2023 |
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IEEE Journal of Biomedical and Health Informatics |
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JBHI |
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27 |
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7 |
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3302-3313 |
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In recent years, several deep learning models have been proposed to accurately quantify and diagnose cardiac pathologies. These automated tools heavily rely on the accurate segmentation of cardiac structures in MRI images. However, segmentation of the right ventricle is challenging due to its highly complex shape and ill-defined borders. Hence, there is a need for new methods to handle such structure's geometrical and textural complexities, notably in the presence of pathologies such as Dilated Right Ventricle, Tricuspid Regurgitation, Arrhythmogenesis, Tetralogy of Fallot, and Inter-atrial Communication. The last MICCAI challenge on right ventricle segmentation was held in 2012 and included only 48 cases from a single clinical center. As part of the 12th Workshop on Statistical Atlases and Computational Models of the Heart (STACOM 2021), the M&Ms-2 challenge was organized to promote the interest of the research community around right ventricle segmentation in multi-disease, multi-view, and multi-center cardiac MRI. Three hundred sixty CMR cases, including short-axis and long-axis 4-chamber views, were collected from three Spanish hospitals using nine different scanners from three different vendors, and included a diverse set of right and left ventricle pathologies. The solutions provided by the participants show that nnU-Net achieved the best results overall. However, multi-view approaches were able to capture additional information, highlighting the need to integrate multiple cardiac diseases, views, scanners, and acquisition protocols to produce reliable automatic cardiac segmentation algorithms. |
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Admin @ si @ MCI2023 |
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3880 |
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Giuseppe Pezzano; Oliver Diaz; Vicent Ribas Ripoll; Petia Radeva |
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CoLe-CNN+: Context learning – Convolutional neural network for COVID-19-Ground-Glass-Opacities detection and segmentation |
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2021 |
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Computers in Biology and Medicine |
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CBM |
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136 |
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104689 |
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The most common tool for population-wide COVID-19 identification is the Reverse Transcription-Polymerase Chain Reaction test that detects the presence of the virus in the throat (or sputum) in swab samples. This test has a sensitivity between 59% and 71%. However, this test does not provide precise information regarding the extension of the pulmonary infection. Moreover, it has been proven that through the reading of a computed tomography (CT) scan, a clinician can provide a more complete perspective of the severity of the disease. Therefore, we propose a comprehensive system for fully-automated COVID-19 detection and lesion segmentation from CT scans, powered by deep learning strategies to support decision-making process for the diagnosis of COVID-19. |
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MILAB; no menciona |
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Admin @ si @ PDR2021 |
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3635 |
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Diana Ramirez Cifuentes; Ana Freire; Ricardo Baeza Yates; Nadia Sanz Lamora; Aida Alvarez; Alexandre Gonzalez; Meritxell Lozano; Roger Llobet; Diego Velazquez; Josep M. Gonfaus; Jordi Gonzalez |
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Characterization of Anorexia Nervosa on Social Media: Textual, Visual, Relational, Behavioral, and Demographical Analysis |
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2021 |
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Journal of Medical Internet Research |
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JMIR |
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23 |
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7 |
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e25925 |
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Background: Eating disorders are psychological conditions characterized by unhealthy eating habits. Anorexia nervosa (AN) is defined as the belief of being overweight despite being dangerously underweight. The psychological signs involve emotional and behavioral issues. There is evidence that signs and symptoms can manifest on social media, wherein both harmful and beneficial content is shared daily. |
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ISE |
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Admin @ si @ RFB2021 |
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3665 |
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O.F.Ahmad; Y.Mori; M.Misawa; S.Kudo; J.T.Anderson; Jorge Bernal |
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Establishing key research questions for the implementation of artificial intelligence in colonoscopy: a modified Delphi method |
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2021 |
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Endoscopy |
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END |
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53 |
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9 |
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893-901 |
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BACKGROUND : Artificial intelligence (AI) research in colonoscopy is progressing rapidly but widespread clinical implementation is not yet a reality. We aimed to identify the top implementation research priorities. METHODS : An established modified Delphi approach for research priority setting was used. Fifteen international experts, including endoscopists and translational computer scientists/engineers, from nine countries participated in an online survey over 9 months. Questions related to AI implementation in colonoscopy were generated as a long-list in the first round, and then scored in two subsequent rounds to identify the top 10 research questions. RESULTS : The top 10 ranked questions were categorized into five themes. Theme 1: clinical trial design/end points (4 questions), related to optimum trial designs for polyp detection and characterization, determining the optimal end points for evaluation of AI, and demonstrating impact on interval cancer rates. Theme 2: technological developments (3 questions), including improving detection of more challenging and advanced lesions, reduction of false-positive rates, and minimizing latency. Theme 3: clinical adoption/integration (1 question), concerning the effective combination of detection and characterization into one workflow. Theme 4: data access/annotation (1 question), concerning more efficient or automated data annotation methods to reduce the burden on human experts. Theme 5: regulatory approval (1 question), related to making regulatory approval processes more efficient. CONCLUSIONS : This is the first reported international research priority setting exercise for AI in colonoscopy. The study findings should be used as a framework to guide future research with key stakeholders to accelerate the clinical implementation of AI in endoscopy. |
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Admin @ si @ AMM2021 |
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3670 |
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Shiqi Yang; Yaxing Wang; Joost Van de Weijer; Luis Herranz; Shangling Jui |
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Exploiting the Intrinsic Neighborhood Structure for Source-free Domain Adaptation |
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2021 |
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Thirty-fifth Conference on Neural Information Processing Systems (NeurIPS 2021) |
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Domain adaptation (DA) aims to alleviate the domain shift between source domain and target domain. Most DA methods require access to the source data, but often that is not possible (e.g. due to data privacy or intellectual property). In this paper, we address the challenging source-free domain adaptation (SFDA) problem, where the source pretrained model is adapted to the target domain in the absence of source data. Our method is based on the observation that target data, which might no longer align with the source domain classifier, still forms clear clusters. We capture this intrinsic structure by defining local affinity of the target data, and encourage label consistency among data with high local affinity. We observe that higher affinity should be assigned to reciprocal neighbors, and propose a self regularization loss to decrease the negative impact of noisy neighbors. Furthermore, to aggregate information with more context, we consider expanded neighborhoods with small affinity values. In the experimental results we verify that the inherent structure of the target features is an important source of information for domain adaptation. We demonstrate that this local structure can be efficiently captured by considering the local neighbors, the reciprocal neighbors, and the expanded neighborhood. Finally, we achieve state-of-the-art performance on several 2D image and 3D point cloud recognition datasets. Code is available in https://github.com/Albert0147/SFDA_neighbors. |
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Online; December 7-10, 2021 |
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NIPS |
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LAMP; 600.147; 600.141 |
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Admin @ si @ |
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3691 |
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Dustin Carrion Ojeda; Hong Chen; Adrian El Baz; Sergio Escalera; Chaoyu Guan; Isabelle Guyon; Ihsan Ullah; Xin Wang; Wenwu Zhu |
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NeurIPS’22 Cross-Domain MetaDL competition: Design and baseline results |
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2022 |
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Understanding Social Behavior in Dyadic and Small Group Interactions |
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191 |
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24-37 |
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We present the design and baseline results for a new challenge in the ChaLearn meta-learning series, accepted at NeurIPS'22, focusing on “cross-domain” meta-learning. Meta-learning aims to leverage experience gained from previous tasks to solve new tasks efficiently (i.e., with better performance, little training data, and/or modest computational resources). While previous challenges in the series focused on within-domain few-shot learning problems, with the aim of learning efficiently N-way k-shot tasks (i.e., N class classification problems with k training examples), this competition challenges the participants to solve “any-way” and “any-shot” problems drawn from various domains (healthcare, ecology, biology, manufacturing, and others), chosen for their humanitarian and societal impact. To that end, we created Meta-Album, a meta-dataset of 40 image classification datasets from 10 domains, from which we carve out tasks with any number of “ways” (within the range 2-20) and any number of “shots” (within the range 1-20). The competition is with code submission, fully blind-tested on the CodaLab challenge platform. The code of the winners will be open-sourced, enabling the deployment of automated machine learning solutions for few-shot image classification across several domains. |
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HUPBA; no menciona |
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Admin @ si @ CCB2022 |
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3802 |
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Adam Fodor; Rachid R. Saboundji; Julio C. S. Jacques Junior; Sergio Escalera; David Gallardo Pujol; Andras Lorincz |
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Multimodal Sentiment and Personality Perception Under Speech: A Comparison of Transformer-based Architectures |
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2022 |
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Understanding Social Behavior in Dyadic and Small Group Interactions |
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173 |
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218-241 |
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Human-machine, human-robot interaction, and collaboration appear in diverse fields, from homecare to Cyber-Physical Systems. Technological development is fast, whereas real-time methods for social communication analysis that can measure small changes in sentiment and personality states, including visual, acoustic and language modalities are lagging, particularly when the goal is to build robust, appearance invariant, and fair methods. We study and compare methods capable of fusing modalities while satisfying real-time and invariant appearance conditions. We compare state-of-the-art transformer architectures in sentiment estimation and introduce them in the much less explored field of personality perception. We show that the architectures perform differently on automatic sentiment and personality perception, suggesting that each task may be better captured/modeled by a particular method. Our work calls attention to the attractive properties of the linear versions of the transformer architectures. In particular, we show that the best results are achieved by fusing the different architectures{’} preprocessing methods. However, they pose extreme conditions in computation power and energy consumption for real-time computations for quadratic transformers due to their memory requirements. In turn, linear transformers pave the way for quantifying small changes in sentiment estimation and personality perception for real-time social communications for machines and robots. |
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HuPBA; no menciona |
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Admin @ si @ FSJ2022 |
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3769 |
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German Barquero; Johnny Nuñez; Sergio Escalera; Zhen Xu; Wei-Wei Tu; Isabelle Guyon |
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Didn’t see that coming: a survey on non-verbal social human behavior forecasting |
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2022 |
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Understanding Social Behavior in Dyadic and Small Group Interactions |
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173 |
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139-178 |
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Non-verbal social human behavior forecasting has increasingly attracted the interest of the research community in recent years. Its direct applications to human-robot interaction and socially-aware human motion generation make it a very attractive field. In this survey, we define the behavior forecasting problem for multiple interactive agents in a generic way that aims at unifying the fields of social signals prediction and human motion forecasting, traditionally separated. We hold that both problem formulations refer to the same conceptual problem, and identify many shared fundamental challenges: future stochasticity, context awareness, history exploitation, etc. We also propose a taxonomy that comprises
methods published in the last 5 years in a very informative way and describes the current main concerns of the community with regard to this problem. In order to promote further research on this field, we also provide a summarized and friendly overview of audiovisual datasets featuring non-acted social interactions. Finally, we describe the most common metrics used in this task and their particular issues. |
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Virtual; June 2022 |
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HuPBA; no proj |
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Admin @ si @ BNE2022 |
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3766 |
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Meysam Madadi; Hugo Bertiche; Wafa Bouzouita; Isabelle Guyon; Sergio Escalera |
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Learning Cloth Dynamics: 3D+Texture Garment Reconstruction Benchmark |
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2021 |
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Proceedings of Machine Learning Research |
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133 |
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57-76 |
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Human avatars are important targets in many computer applications. Accurately tracking, capturing, reconstructing and animating the human body, face and garments in 3D are critical for human-computer interaction, gaming, special effects and virtual reality. In the past, this has required extensive manual animation. Regardless of the advances in human body and face reconstruction, still modeling, learning and analyzing human dynamics need further attention. In this paper we plan to push the research in this direction, e.g. understanding human dynamics in 2D and 3D, with special attention to garments. We provide a large-scale dataset (more than 2M frames) of animated garments with variable topology and type, calledCLOTH3D++. The dataset contains RGBA video sequences paired with its corresponding 3D data. We pay special care to garment dynamics and realistic rendering of RGB data, including lighting, fabric type and texture. With this dataset, we hold a competition at NeurIPS2020. We design three tracks so participants can compete to develop the best method to perform 3D garment reconstruction in a sequence from (1) 3D-to-3D garments, (2) RGB-to-3D garments, and (3) RGB-to-3D garments plus texture. We also provide a baseline method, based on graph convolutional networks, for each track. Baseline results show that there is a lot of room for improvements. However, due to the challenging nature of the problem, no participant could outperform the baselines. |
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HUPBA; no proj |
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Admin @ si @ MBB2021 |
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3655 |
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