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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Assessing agonist efficacy in an uncertain Em world |
Type |
Conference Article |
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Year |
2012 |
Publication |
40th Keystone Symposia on mollecular and celular biology |
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Pages |
79 |
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Abstract |
The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed. |
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Address |
Fairmont Banff Springs, Banff, Alberta, Canada |
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Keystone Symposia |
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Keystone Symposia |
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Editor |
A. Christopoulus and M. Bouvier |
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Language |
english |
Summary Language |
english |
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Keystone Symposia |
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KSMCB |
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IAM |
Approved |
no |
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Call Number |
IAM @ iam @ RGG2012 |
Serial |
1855 |
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Author |
Eric Amiel |
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Title |
Visualisation de vaisseaux sanguins |
Type |
Report |
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Year |
2005 |
Publication |
Rapport de Stage |
Abbreviated Journal |
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Université Paul Sabatier Toulouse III |
Thesis |
Bachelor's thesis |
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Publisher |
Université Paul Sabatier Toulouse III |
Place of Publication |
Toulouse |
Editor |
Enric Marti |
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Language |
French |
Summary Language |
French |
Original Title |
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Series Editor |
IUP Systèmes Intelligents |
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IAM |
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Call Number |
IAM @ iam @ Ami2005 |
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1690 |
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Author |
Patricia Marquez; Debora Gil ; Aura Hernandez-Sabate |
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Title |
Error Analysis for Lucas-Kanade Based Schemes |
Type |
Conference Article |
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Year |
2012 |
Publication |
9th International Conference on Image Analysis and Recognition |
Abbreviated Journal |
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Volume |
7324 |
Issue |
I |
Pages |
184-191 |
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Keywords |
Optical flow, Confidence measure, Lucas-Kanade, Cardiac Magnetic Resonance |
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Abstract |
Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures. |
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Address |
Aveiro, Portugal |
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Springer-Verlag Berlin Heidelberg |
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english |
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Campilho, Aurélio and Kamel, Mohamed |
Series Title |
Lecture Notes in Computer Science |
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LNCS |
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ISSN |
0302-9743 |
ISBN |
978-3-642-31294-6 |
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ICIAR |
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IAM |
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Call Number |
IAM @ iam @ MGH2012a |
Serial |
1899 |
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Author |
Josep Llados; J. Lopez-Krahe; Enric Marti |
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Title |
A Hough-based method for hatched pattern detection in maps and diagrams. |
Type |
Miscellaneous |
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Year |
1999 |
Publication |
Proceedings of the International Conference on Document Analysis and Recognition. |
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Bangalore-India |
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DAG |
Approved |
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Call Number |
DAG @ dag @ LlM1999b |
Serial |
1 |
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Author |
Felipe Lumbreras; Ramon Baldrich; Maria Vanrell; Joan Serrat; Juan J. Villanueva |
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Title |
Multiresolution colour texture representations for tile classification |
Type |
Miscellaneous |
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Year |
1999 |
Publication |
Proceedings of the VIII Symposium Nacional de Reconocimiento de Formas y Analisis de Imagenes |
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Bilbao |
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ADAS;CIC |
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Call Number |
ADAS @ adas @ LBV1999a |
Serial |
3 |
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Author |
David Guillamet; Jordi Vitria |
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Title |
Using Eigenspace analysis of color distributions for object recognition |
Type |
Miscellaneous |
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Year |
1999 |
Publication |
Proceedings of the VIII Symposium Nacional de Reconocimiento de Formas y Analisis de Imagenes |
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OR;MV |
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Call Number |
BCNPCL @ bcnpcl @ GuV1999a |
Serial |
5 |
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Author |
A. Pujol; Felipe Lumbreras; X. Varona; Juan J. Villanueva |
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Title |
Template matching through invariant eigenspace projection. |
Type |
Miscellaneous |
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Year |
1999 |
Publication |
Proceedings of the VIII Symposium Nacional de Reconocimiento de Formas y Analisis de Imagenes. |
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ADAS |
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Call Number |
ADAS @ adas @ PLV1999 |
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6 |
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Author |
Josep Llados; Felipe Lumbreras; X. Varona |
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Title |
A multidocument platform for automatic reading of identity cards. |
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Miscellaneous |
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1999 |
Publication |
Proceedings of the VIII Symposium Nacional de Reconocimiento de Formas y Analisis de Imagenes. |
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ADAS;DAG |
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ADAS @ adas @ LLV1999 |
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7 |
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Author |
A. Martinez; Jordi Vitria |
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Title |
Learning mixture models with the EM algorithm and genetic algorithms |
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Report |
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Year |
1998 |
Publication |
CVC Technical Report #23 |
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CVC (UAB) |
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OR;MV |
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BCNPCL @ bcnpcl @ MaV1998a |
Serial |
8 |
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Author |
A.F. Sole; Antonio Lopez; Cristina Cañero; Petia Radeva; J. Saludes |
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Title |
Crease enhancement diffusion |
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Miscellaneous |
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1999 |
Publication |
Proceedings of the VIII Symposium Nacional de Reconocimiento de Formas y Analisis de Imagenes |
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ADAS;MILAB |
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Call Number |
ADAS @ adas @ SLC1999 |
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9 |
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